Forschungsbericht 2025

Systemverfahrenstechnik V-4

Leitung: Skiborowski, Mirko
Oberingenieur: Waluga, Thomas

Institut auf TORE
Institutswebsite

Within the scope of the research activities, the institute’s researcher develop novel concepts and methods for process synthesis and optimization of intensive processes in the field of process engineering and bioprocess engineering. The focus here is on integrated reaction and separation processes, as well as energy-integrated and hybrid separation processes. The aim of the methodological work is to make the development processes more resource and time efficient and to enable a targeted evaluation and optimization of competing process concepts, so that future processes offer maximum sustainability and safety at minimum cost.

Publikationen

• Rapid multi-criteria screening of energy-integrated distillation processes for nonideal mixtures - Journal Article
  Adami, Momme; Espert, Dennis; Skiborowski, Mirko
  Separation and purification technology 377: 134463 (2025)
  Open Access | Publisher DOI
  
  
• Integrating optimal design of experiments and superstructure optimization under uncertainties for the design of membrane processes - Journal Article
  Kaiser, Stefanie; Schlüter, Stefan; Skiborowski, Mirko; Engell, Sebastian
  Chemical Engineering Journal 525: 170385 (2025)
  Open Access | Publisher DOI
  
  
• Next-generation pervaporation-assisted distillation: Recent advances in process intensification - Review Article
  Polyakova, Maria; Skiborowski, Mirko
  Chemical Engineering and Processing Process Intensification 216: 110416 (2025)
  Open Access | Publisher DOI
  
  
• Beyond dividing wall columns: Improved process intensification through liquid-only transfer and heat integration - Journal Article
  Adami, Momme; Bertram, Sina; Espert, Dennis; Skiborowski, Mirko
  Chemical Engineering and Processing - Process Intensification 218: 110559 (2025)
  Open Access | Publisher DOI
  
  
• Magnetic Resonance Imaging of Structured Packings: Overcoming Spatial, Signal, and Geometric Challenges - Conference Presentation
  Rennebaum, Hannah Sophie; Dobschall, Alina; Benders, Stefan; Skiborowski, Mirko; Penn, Alexander
  18th International Conference on Magnetic Resonance Microscopy, ICMRM 2025
  
  
• Debottlenecking a 2-phase multi-enzymatic cascade by an enzyme membrane reactor – Modelling and experimental validation - Journal Article
  von Ziegner, Francesca; Brauckmann, Grit; Filiz, Volkan; Brinkmann, Torsten; Bubenheim, Paul; Waluga, Thomas
  Chemical engineering and processing 217: 110499 (2025)
  Open Access | Publisher DOI
  
  
• Optimal design of extraction-distillation hybrid processes by combining equilibrium and rate-based modeling - Journal Article
  Kruber, Kai F.; Kabra, Anjali; Polte, Lukas; Jupke, Andreas; Skiborowski, Mirko
  Systems & Control Transactions 4: 1005-1010 (2025)
  Open Access | Publisher DOI
  
  
• Systematic design of structured packings based on shape optimization - Journal Article
  Dobschall, Alina; Michaelis, Elvis; Skiborowski, Mirko
  Systems & Control Transactions 4: 1077-1082 (2025)
  Open Access | Publisher DOI
  
  
• Axial dispersion modelling of the residence time distribution in a millistructured plate reactor - Journal Article
  Schaare, Lucas; Rave, Alexander; Kuwertz, Rafael; Fieg, Georg; Skiborowski, Mirko
  Chemical Engineering and Processing - Process Intensification 213: 110295 (2025)
  Open Access | Publisher DOI
  
  
• Refrigerant selection and cycle design for industrial heat pump applications exemplified for distillation processes - Journal Article
  Schnurr, Jonas; Adami, Momme; Skiborowski, Mirko
  Systems & Control Transactions 4: 1306-1311 (2025)
  Open Access | Publisher DOI
  
  
• Pimp my distillation sequence - shortcut-based screening of intensified configurations - Journal Article
  Adami, Momme; Espert, Dennis; Skiborowski, Mirko
  Systems & Control Transactions 4: 2630-2636 (2025)
  Open Access | Publisher DOI
  
  
• Parameter distribution analysis for enzyme kinetic models with inhibition - Journal Article
  Waluga, Thomas; Rosenthal, Katrin
  Industrial and Engineering Chemistry Research 64 (25): 12536-12544 (2025)
  Publisher DOI
  
  
• Electrified distillation – optimized design of closed cycle heat pumps with refrigerant selection and flash-enhanced mechanical vapor recompression - Journal Article
  Adami, Momme; Schnurr, Jonas; Skiborowski, Mirko
  Applied Thermal Engineering 273: 126559 (2025)
  Open Access | Publisher DOI
  
  
• Hybrid optimization methodologies for the design of chemical processes - Book Part
  Kruber, Kai; Kinau, Siv Magdalena; Skiborowski, Mirko
  De Gruyter 978-3-11-138338-5: 305-341 (2025)
  Publisher DOI
  
  
• Thermally coupled distillation columns without vapor transfer – Current state and further needs - Journal Article
  Horsch, Anna Sophia; Skiborowski, Mirko
  Separation and Purification Technology 354: 128762 (2025)
  Open Access | Publisher DOI
  
  
• Novel insights into the liquid distribution in structured packings - Conference Presentation
  Rennebaum, Hannah Sophie; Dobschall, Alina; Conje, Fin; Skiborowski, Mirko; Penn, Alexander
  Jahrestreffen der DECHEMA/VDI-Fachgruppe Fluidverfahrenstechnik 2025
  
  
• Analytical and numerical approaches to the analysis of progress curves: a methodological comparison - Journal Article
  Waluga, Thomas; von Ziegner, Francesca; Skiborowski, Mirko
  Process Biochemistry 151: 1-13 (2025)
  Open Access | Publisher DOI
  
  
• Hybrid optimization methodologies for the design of chemical processes - Book Part
  Kruber, Kai; Kinau, Siv Magdalena; Skiborowski, Mirko
  De Gruyter 978-3-11-138343-9: 305-342 (2025)
  Publisher DOI
  
  
• Electrifying distillation − Optimization-based evaluation of internally heat-integrated distillation columns - Journal Article
  Adami, Momme; Farheen, Kayenat; Skiborowski, Mirko
  Separation and Purification Technology 360 (3): 131061 (2025)
  Open Access | Publisher DOI
  
  
• Open and FAIR data for nanofiltration in organic media: a unified approach - Journal Article
  Van Buggenhout, Simon; Ignacz, Gergo; Caspers, Scout; Dhondt, Robin; Lenaerts, Marie; Lenaerts, Nathalie; Hosseinabadi, Sareh Rezaei; Nulens, Ines; Koeckelberghs, Guy; Ren, Yi; Lively, Ryan P.; Rabiller-Baudry Murielle; Lim, Ki Min; Ghazali, Nazlee; Coronas, Joaquin; Abel, Milan; Wessling, Matthias; Skiborowski, Mirko; Oxley, Adam; Han, Seokju; Livingston, Andrew; Yi, Zhuan; Gao, Congjie; Guan, Kecheng; Gonzales, Ralph Rolly; Matsuyama, Hideto; Bettahalli, Srivatsa NM.; McCutcheon, Jeffrey R.; Radmanesh, Farzaneh; Benes, Nieck E.; Tashvigh, Akbar Asadi; Fang, Qing; Zhang, Kaisong; Chen, Guining; Jin, Wanqin; Zhang, Yatao; Zhang, Chun-Xu; Liu, Mei-ling; Sun, Shi-peng; Buekenhoudt, Anita; Zhao, Chen; Bruggen, Bart Van der; Kim, Jeong F.; Condes, Lucas C.; Webb, Matthew T.; Galizia, Michele; Alhazmi, Banan; Upadhyaya, Lakshmeesha; Nunes, Suzana; Kim, Dae Woo; Schröter, Henrik; Kragl, Udo; Störtte, Sven; Vorholt, Andreas J.; Culfaz-Emecen, P. Zeynep; Chau, John; Winnubst, Louis; Yushkin, Alexey; Vorholt, Andreas J.; Pizzoccaro-Zilamy, Marie Alix; Sirkar, Kamalesh K.; Shao, Lu; Szekely, Gyorgy; Vankelecom, Ivo F. J.; Verbeke, Rhea
  Journal of Membrane Science 713: 123356 (2025)
  Publisher DOI
  
  
• Wave-resolving Voronoi model of the Rouse number for sediment entrainment - Journal Article
  Lawen, Johannes
  Ocean Science 21 (3): 877–896 (2025)
  Open Access | Publisher DOI
  
  
• Optimization-based process synthesis by phenomena-based building blocks and an MINLP framework featuring structural screening - Journal Article
  Krone, David; Esche, Erik; Skiborowski, Mirko; Repke, Jens-Uwe
  Computers and Chemical Engineering 194: 108955 (2025)
  Open Access | Publisher DOI
  
  
• HOOU an der TU Hamburg : Jahresbericht 2024 - Text
  Alff, Thies Lennart; Blessing, Benjamin; Bock, Katrin; Carels, Fabian; Coordes, Marcus; Henkel, Moritz; Contreras-Campana, Christian Javier; Oliveira-Guglielmi, Paula de; Hausig, Malte; Hofmann, Alexander; Holm, Malte; Kitzberger, Magdalena; Kaiser, Jan; Kruber, Kai; Leyva Amezcua, Leonardo; Lüssenhop, Phillipp; Musawi, Anusch; Rose, Jana Maria-Magdalena; Panke, Jana; Rehman, Hanan; Shahgoli, Selva; Shenoy, Sucheth; Seidelmann, Maren; Schmeckpeper, Dennis; Scherpe, Erik; Schäfers, Johannes; Schielein, Dorothee; Weber, Valentin Severin; Wichmann, Stephanie; Zeeden, Kasimir
  Technische Universität Hamburg (2025)
  Open Access
  
  

Forschungsdaten

• Experimental data of the corresponding publication of Debottlenecking a 2-Phase Multi-Enzymatic Cascade by an Enzyme Membrane Reactor – Modelling and Experimental Validation - Experimental Data
  Waluga, Thomas
  Open Access
  
  

Projekte

• IKKO - Intensivierung einer Knallgasfermentation zur Herstellung von klimaneutralen Ölen - Maschinelles Lernen und modellgestützte Prozessoptimierung und -regelung
  Bundesministerium für Forschung, Technologie und Raumfahrt (BMFTR); Laufzeit 2025-2027
  Projektleitung: Waluga, Thomas
  Mitarbeitende: Klein, Maximilian
  Externe beteiligte Einrichtungen: COLIPI GmbH; Ingenieurbüro Dr.-Ing. Schoop GmbH
  
  
• I³-Junior-Project – Investigation of impact and improvements of additive manufacturing technologies for structured packings in distillation columns
  Technische Universität Hamburg; Laufzeit 2025-2026
  Projektleitung: Dobschall, Alina; Maiwald, Maria Isabelle
  
  
• SCOPE-MRI - Entwurf von strukturierten Packungen mittels CFD-basierter Optimierung, Absorptionsexperimenten und Magnetresonanztomographie
  Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2024-2027
  Projektleitung: Penn, Alexander; Skiborowski, Mirko
  
  
• Scoping Workshop "Synergien in der Bioreaktiven Trenntechnik: Integration von Biokatalyse, Trenntechnik und Systemverfahrenstechnik zur Erreichung nachhaltiger Produktionsprozesse.
  VW-Stiftung National; Laufzeit 2024-2025
  Projektleitung: Skiborowski, Mirko
  Co-Projektleitung: Liese, Andreas; Smirnova, Irina
  
  
• I³-Junior-Project – Investigation of distributor designs for an enhanced liquid distribution in structured packings for thermal separation processes
  Technische Universität Hamburg; Laufzeit 2024-2025
  Projektleitung: Dobschall, Alina
  
  
• AutoOptiMilli - Entwicklung und Demonstration eines autonomen Systems zur Kl-basierten Optimierung eines milli-strukturierten Plattenreaktors
  Bundesministerium für Wirtschaft und Klimaschutz (BMWK); Laufzeit 2024-2026
  Projektleitung: Skiborowski, Mirko
  
  
• SFB 1615 - Teilprojekt B06: Systematische Multiskalenmodellierung und Designkonzept für SMARTe Reaktoren
  Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2023-2027
  Projektleitung: Skiborowski, Mirko; Schlüter, Michael
  Mitarbeitende: Kinau, Siv Magdalena; Weiland, Christian; Hoffmann, Marko; Paschalidis, Leandros
  
  
• Bausteinbasierte automatische Prozesssynthese intensivierter Trennprozesse
  Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2023-2026
  Projektleitung: Skiborowski, Mirko
  Externe beteiligte Einrichtungen: Bundesanstalt für Materialforschung und -prüfung (BAM)
  
  
• Entwicklung und experimentelle Validierung einer molekulardynamischen Simulationsmethode zur Vorausberechnung von Adsorptionsisothermen von Proteinen
  Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2021-2025
  Projektleitung: Jakobtorweihen, Sven; Smirnova, Irina; Waluga, Thomas
  
  
• MuPha2 - Multienzymkaskade im 2-Phasensystem
  Deutsche Forschungsgemeinschaft (DFG); Laufzeit 2017-2025
  Projektleitung: Bubenheim, Paul; Waluga, Thomas
  Mitarbeitende: von Ziegner, Francesca
  
  

Kooperationspartner

• TU Berlin ⇒ Arbeitsgruppe: Dr. Erik Esche
• Fraunhofer ICT
• Fraunhofer ITWM ⇒ Abteilung: Prof. Dr. Michael Bortz
• Ehrfeld Mikrotechnik
• Ingenieurbüro Dr.-Ing. Schoop
• Montz (Koch-Glitsch)
• BASF

Großgeräte

• Mehrfachbehäter-Labordestillationsanlage
  Hersteller: NORMAG Labor- und Prozesstechnik
  DOI: 10.15480/882.14097
  DFG-Geräteklassifikation: 1300 -- Destillier- und Fraktioniergeräte, Rektifiziergeräte
  
  
• Multifunktionale Rektifikationskolonne
  Hersteller: Julius Montz GmbH
  DOI: 10.15480/882.14098
  DFG-Geräteklassifikation: 1300 -- Destillier- und Fraktioniergeräte, Rektifiziergeräte