Hochporöse Aerogelpartikel aus Protein als Trägermatrix für sensitive und sensorisch störende Stoffe in Lebensmitteln

The aim of this research project is to develop a coating procedure for micrometre-sized (<100 µm) and light weighting protein-based aerogels using the spouted bed technology. This technique is frequently used for industrial processes like spray granulation, coating or drying of particles, when intensive contacting of gas and solid particles is required. For processing of such fine particles stable spouting operating conditions can be achieved, when particles are highly dispersed in the apparatus at high gas velocities (dilute spouting regime). This process is excellent for coating of small particles with thin, uniform and dense layers giving the possibility to produce sustainable particles, which enable controlled drug release in human body at different pH levels.

Moreover, the project applies a modelling approach to optimize the coating procedure by means of the coupled CFD (Computational Fluid Dynamics) - DEM (Discrete Element Method) approach. Additionally, the structure of the particles is modelled with DEM.

Stichworte

• Coating
• Wirbelschicht

Publikationen

• Selmer, Ilka and Kleemann, Christian and Kulozik, Ulrich and Heinrich, Stefan and Smirnova, Irina: Development of egg white protein aerogels as new matrix material for microencapsulation in food. Journal of Supercritical Fluids, 106: S. 42--49, 2015. , DOI: 10.1016/j.supflu.2015.05.023
• Antonyuk, Sergiy and Heinrich, Stefan and Gurikov, Pavel and Raman, Subrahmanyam and Smirnova, Irina: Influence of coating and wetting on the mechanical behaviour of highly porous cylindrical aerogel particles. Powder Technology, 285: S. 34--43, 2015. , DOI: 10.1016/j.powtec.2015.05.004
• Alnaif, M. and Antonyuk, S. and Hentzschel, C.M. and Leopold, C.S. and Heinrich, S. and Smirnova, I.: A novel process for coating of silica aerogel microspheres for controlled drug release applications. 2012. , DOI: 10.1016/j.micromeso.2012.02.009
• Antonyuk, S. and Heinrich, S. and Smirnova, I.: Discrete Element Study of aerogel particle dynamics in a spouted bed apparatus. 8 2012. , DOI: DOI: 10.1002/ceat.201200083
• Alnaif, M. and Smirnova, I. and Antonyuk, S. and Heinrich, S.: Production and coating of silica aerogel microspheres for advance drug delivery. 2010.
• Goncalves, V. S. S. and Gurikov, P. and Poejo, J. and Matias, A. A. and Heinrich, S. and Duarte, C. M. M. and Smirnova, I.: Alginate-based hybrid aerogel microparticles for mucosal drug delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 107: S. 160--170, 2016. , DOI: 10.1016/j.ejpb.2016.07.003
• Spettl, Aaron and Bachstein, Simon and Dosta, Maksym and Goslinska, Monika and Heinrich, Stefan and Schmidt, Volker: Bonded-particle extraction and stochastic modeling of internal agglomerate structures. Advanced Powder Technology, 27(4): S. 1761--1774, 2016. , DOI: 10.1016/j.apt.2016.06.007